Who's on First? maybe not Boston. Maybe Boulder's claim of being a 140-year-old innovation district is valid. The Magazine INC describes Boulder's entrepreneurial history in detail.
I do believe when innovation is engrained so thoroughly into the DNA of a corporation or a city or a person, they manifest that quality. They become innovation. Labels don't stick.
Brad Feld wrote a book about Boulder: Start-Up Communities. It will likely make you want to move to Boulder but I think the intent was to inspire you on a 20-year quest to invest in your own local entrepreneurial community.
HERE is the white paper from Marc Nagar about the five ingredients they see as necessary for an entrepreneurial ecosystem.